Key result
Continuous-wave Doppler detects PAD with ~82% sensitivity and high specificity, unaffected by diabetes.
Why the study?
There is limited evidence investigating the diagnostic accuracy of continuous-wave Doppler for detecting peripheral arterial disease in patients with and without diabetes.
Does continuous-wave Doppler accurately detect peripheral arterial disease in people with and without diabetes?
Cross-Sectional (n=396)
Does continuous-wave Doppler accurately detect peripheral arterial disease in people with and without diabetes?
Continuous-wave Doppler is a fair diagnostic tool for detecting peripheral arterial disease, and its diagnostic accuracy is not compromised by the presence of diabetes.
Answers are grounded in this paper and cite their sources.
May support continuous-wave Doppler for PAD screening regardless of diabetes; leaves open prospective validation before changing practice.
BACKGROUND: Continuous-wave Doppler is frequently used for detecting peripheral arterial disease in patients with diabetes; however, there is limited evidence investigating diagnostic accuracy. This study aimed to determine sensitivity and specificity of continuous-wave Doppler for detecting peripheral arterial disease in populations with, and without, diabetes and to investigate the influence of disease severity on sensitivity of continuous-wave Doppler for detecting peripheral arterial disease. RESULTS: Data from 396 participants were included. Using colour Duplex ultrasound as reference standard (N=66), printed continuous-wave Doppler waveform analysis sensitivity was 81.75% (95% confidence interval: 76.75 to 85.88) and specificity 89.34% (95% confidence interval: 82.62 to 93.67). Printed continuous-wave Doppler waveform analysis sensitivity for peripheral arterial disease was comparable to sensitivity calculated using angiography as the reference standard (81.67%; 95% confidence interval: 69.56 to 90.48). Sensitivity and specificity were unaffected by diabetes diagnosis (n = 176), sensitivity 82.76% (95% confidence interval: 74.86 to 88.55), and specificity 88.33% (95% confidence interval: 77.82 to 94.23). CONCLUSION: Continuous-wave Doppler is a fair assessment tool for peripheral arterial disease in a community-based sample with suspected peripheral arterial disease. Diagnostic accuracy of continuous-wave Doppler for peripheral arterial disease is unaffected by the presence of diabetes.
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Tehan et al. (2018) conducted a cross-sectional in Peripheral arterial disease (n=396). Continuous-wave Doppler vs. Colour Duplex ultrasound (reference standard) was evaluated on Sensitivity for detecting peripheral arterial disease using colour Duplex ultrasound as reference standard (95% CI 76.75 to 85.88). Continuous-wave Doppler demonstrated 81.75% sensitivity (95% CI 76.75-85.88) and 89.34% specificity for detecting peripheral arterial disease, with diagnostic accuracy unaffected by diabetes.
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