Key result
ECE inhibitor cuts mortality ~62% and ameliorates angiotensin II-induced cardiac damage in rats.
Why the study?
The effect of endothelin-converting enzyme inhibition on angiotensin II-induced cardiac damage was not previously demonstrated.
Does ECE inhibition reduce angiotensin II-induced cardiac damage and mortality in a transgenic rat model of hypertension?
Does ECE inhibition reduce angiotensin II-induced cardiac damage and mortality in a transgenic rat model of hypertension?
Absolute Event Rate: 20% vs 52%
ECE inhibition reduces angiotensin II-induced cardiac damage and mortality in a transgenic rat model, independent of blood pressure reduction.
No takes yet. Share an insight, caveat, or question.
ECE inhibition merits human translation studies; leaves open clinical relevance beyond this dTGR model.
Müller et al. (2002) studied Hypertension and angiotensin II-induced cardiac damage (n=32). ECE inhibitor (RO0687629) vs. Vehicle was evaluated on Mortality rate. ECE inhibitor treatment significantly reduced mortality to 20% versus 52% in untreated controls and ameliorated angiotensin II-induced cardiac damage in rats.
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