Why the study?
Does the endothelin-converting enzyme inhibitor FR901533 improve cardiorenal and hormonal function in a canine model of pacing-induced congestive heart failure?
Does the endothelin-converting enzyme inhibitor FR901533 improve cardiorenal and hormonal function in a canine model of pacing-induced congestive heart failure?
Chronic endothelin-converting enzyme inhibition with FR901533 improves hemodynamics and prevents fluid retention in a canine model of heart failure.
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Supports ECE inhibition in experimental HF; leaves open translation to human therapy.
Wada et al. (2002) studied this question.
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