Key result
FR901533 increases relative wall thickness ~23% in post-MI rats and decreases infarct-zone alpha-smooth muscle actin.
Why the study?
Does FR901533 improve cardiac remodeling in rats after myocardial infarction?
RCT (n=14)
randomized
No
Does FR901533 improve cardiac remodeling in rats after myocardial infarction?
Absolute Event Rate: 0.43% vs 0.35%
p-value: p=<0.05
Selective ECE inhibition with FR901533 improves early cardiac remodeling parameters in a rat model of myocardial infarction.
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Hypothesis-generating for ECE inhibition in post-MI remodeling; leaves open translation to clinical use.
Martin et al. (2000) conducted an RCT in Myocardial Infarction (n=14). FR901533 (ECE inhibitor) vs. no therapy (control) was evaluated on Relative wall thickness (RWT) (p=<0.05). In post-MI rats, 7-day treatment with the ECE inhibitor FR901533 increased relative wall thickness (0.43 vs 0.35, p<0.05) and decreased alpha-smooth muscle actin in the infarct zone.
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