Key result
Solid organ transplantation links to TTS via complex induction mechanisms in pre- and post-transplant phases.
Why the study?
The complex pathophysiological mechanisms and relationship between Takotsubo syndrome and solid organ transplantation, especially heart transplantation, are not completely understood.
This review highlights the pathophysiological mechanisms and relationship between Takotsubo syndrome and heart transplantation.
Raises awareness of TTS around solid organ transplant; leaves open mechanistic and preventive questions for prospective study.
Takotsubo syndrome (TTS) is a clinical syndrome characterized by transient left ventricular dysfunction, ischemic electrocardiographic changes, and minimal release of myocardial enzymes without obstructive coronary artery disease. This syndrome that mimics an acute myocardial infarction is prevalent among female patients and is regarded as a benign medical condition. The precise pathophysiological mechanism of TTS is complex and not completely understood, but specific emotional or physical events precipitate this syndrome that represents a typical condition characterized by interactions between cardiovascular and neuropsychological diseases. In addition, many different neurological disorders, such as stroke, subarachnoid bleeding, head injury, epilepsy, and bacterial meningitis, have directly or indirectly related to TTS; unfortunately, these acute neurological diseases represented the cause of death in patients nominated for organ donation and in particular for the heart donor. This article reviews the relationship between TTS and solid organ transplantation; in particular, this article highlights the possible mechanisms underlying the induction of TTS in pre- and post-transplantation phases and in heart-transplant patients.
No takes yet. Share an insight, caveat, or question.
Giorgi et al. (2017) conducted a review in Takotsubo Syndrome. Solid organ transplantation was evaluated. Solid organ transplantation and its relationship with Takotsubo syndrome involves complex mechanisms of TTS induction in pre- and post-transplantation phases.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: