Key result
Closed-loop stimulation pacing linked to an ~11% EF increase in pediatric patients with ventricular dysfunction.
Why the study?
The feasibility and long-term effects of biventricular pacing with closed loop stimulation in pediatric patients with congenital AV blocks and ventricular dysfunction were not fully understood.
Does closed loop stimulation improve ejection fraction in pediatric patients with a previously implanted pacemaker and ventricular dysfunction?
Comparison
Dual chamber PM INOS(2+)-CLS pacing mode vs prior conventional single or dual chamber pacemaker
Design
Prospective cohort study
Follow-up
Up to 2 years
Authors
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CLS pacing was associated with EF improvement in this small pediatric cohort; leaves open need for randomized trials before wider adoption.
Does closed loop stimulation improve ejection fraction in pediatric patients with a previously implanted pacemaker and ventricular dysfunction?
Absolute Event Rate: 47% vs 36%
p-value: p=<0.003
Closed loop stimulation pacing significantly improves ejection fraction in pediatric patients with ventricular dysfunction and atrioventricular block.
Drago et al. (2007) studied Complete atrioventricular block (CAVB) or CAVB and sinus node dysfunction (SND) with ventricular dysfunction (n=8). Dual chamber pacemaker with closed loop stimulation (CLS) vs. Previous conventional pacemaker (baseline) was evaluated on Ejection fraction (p=<0.003). Closed loop stimulation pacing improved mean ejection fraction from 36% to 47% (P<0.003) over 2 years in pediatric patients with a previously implanted pacemaker and ventricular dysfunction.
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