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February 25, 2005Pacing and Clinical Electrophysiology

Beat‐to‐Beat Heart Rate Adaptation in Pediatric and Late Adolescent Patients with Closed Loop Rate‐Responsive Pacemakers

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Why the study?

Does Closed Loop Stimulation (CLS) pacing provide physiological heart rate adaptation to physical and mental stressors in pediatric and late adolescent patients?

Population

12 pediatric and late adolescent patients with a transvenous implant of Inos2+-CLS dual-chamber pacemaker…

Comparison

Closed Loop Stimulation physiological pacing… vs Baseline resting state and spontaneous heart rate.

Design

Case_series

Authors

FDFabrizio DragoPediatric CardiologyMSMassimo Stefano SilvettiPediatric CardiologyASAntonella De SantisElectrophysiology

Discussion

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Implication

May support CLS rate adaptation in adolescents; hypothesis-generating, requires prospective confirmation before practice change.

Structured PICO

Does Closed Loop Stimulation (CLS) pacing provide physiological heart rate adaptation to physical and mental stressors in pediatric and late adolescent patients?

P
Population
12 pediatric and late adolescent patients (mean age 17 years [range 12-22], 6 males) with a transvenous implant of Inos2+-CLS dual-chamber pacemaker and endocardial leads.
I
Intervention
Closed Loop Stimulation (CLS) physiological pacing mode during rest, mental, standing, and exercise testing.
C
Comparator
Baseline resting state and spontaneous heart rate.
O
Outcome
Beat-to-beat heart rate adaptation (RR intervals) and systolic/diastolic pressures during rest, mental stress, standing, and exercise testing.surrogate

Closed Loop Stimulation (CLS) pacemakers effectively provide physiological heart rate adaptation to both physical and mental stressors in pediatric and late adolescent patients, similar to observations in adults.

Cite This Study

Drago et al. (2005) studied this question.

synapsesocial.com/papers/69d576b662196bac97d9bc40https://doi.org/10.1111/j.1540-8159.2005.09431.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Symptomatology and quality of life in patients with rate‐responsive pacemakers: A double‐blind, randomized, crossover study1989 · 73 citations
  2. 2Intracardiac Impedance to Determine Sympathetic Activity in Rate Responsive Pacing1992 · 96 citations
  3. 3The haemodynamic importance of atrioventricular synchrony and rate increase at rest and during exercise1985 · 107 citations
  4. 4Cardiovascular variability signals: towards the identification of a closed-loop model of the neural control mechanisms1988 · 242 citations
  5. 5A Real-Time QRS Detection Algorithm1985 · 7,893 citations