Why the study?
Does closed loop stimulation (DDD-CLS) pacing improve physiological 24-h beat-to-beat heart rate and blood pressure profiles compared to conventional fixed rate DDD pacing in patients with pacemakers?
Population
17 patients (10 males, aged 46-85 years) implanted with Inos2+ pacemaker; 11 completed the protocol.
Comparison
Closed loop stimulation (DDD-CLS) pacing vs Conventional fixed rate DDD pacing
Design
RCT, randomised cross-over
Follow-up
24 h
Authors
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Supports DDD-CLS over DDD for physiological rate response in pacemaker patients; extends RCT evidence on RR matching to 24-h profiles.
Does closed loop stimulation (DDD-CLS) pacing improve physiological 24-h beat-to-beat heart rate and blood pressure profiles compared to conventional fixed rate DDD pacing in patients with pacemakers?
DDD-CLS pacing provides more physiological heart rate fluctuations and less pronounced drops in heart rate and diastolic blood pressure at the onset of paced rhythm compared to conventional DDD pacing.
Quaglione et al. (2005) studied this question.
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