Key result
Conservative management of CIED infections yields ~8% 12-month mortality, leaving most patients complication-free.
Why the study?
Long-term data on a conservative strategy with pocket revision for CIED infections in patients at high risk for extraction is lacking.
Does conservative management with pocket revision provide acceptable outcomes in selected patients with CIED infections?
Cohort (n=86)
No
Does conservative management with pocket revision provide acceptable outcomes in selected patients with CIED infections?
Conservative management with pocket revision may be a viable alternative to complete lead extraction in carefully selected patients with CIED infections, particularly in the absence of systemic infection.
Supports pocket revision in select CIED infections without systemic signs; leaves open need for RCTs versus extraction.
Cardiac implantable electronic device (CIED) implants are rising in an older, more co-morbid population. The prevalence of CIED infection ranges from 1–4%. Whilst complete extraction of all transvenous hardware is recommended for infected, eroded, or pre-eroding CIEDs, this approach is not without risk and may be unacceptable to some patients. Long-term data on a more conservative strategy is lacking. We report on our experience of conservative management with pocket revision as a primary strategy in carefully selected patients. Method: A retrospective review of all CIED revision procedures was undertaken at a large tertiary center, over a 7-year period, with a mean follow-up timeframe of 39 months. Results: A total of 86 patients underwent 96 revision procedures; 7 patients required further revisions and 13 went on to undergo CIED extraction by the end of the follow-up period. The overall rate of mortality at 12 months was 8.1%, increasing to 24.4% at the end of the follow-up period. Conclusion: Our data provide important outcome information on an alternative strategy to lead extraction in carefully selected patients where the risk of extraction is perceived to be unacceptable. The absence of systemic infection appears to predict better outcomes than previously reported, and over two-thirds of patients remained complication-free at 12 months.
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Llewellyn et al. (2022) conducted a cohort in Cardiac implantable electronic device (CIED) infections (n=86). Conservative management with pocket revision was evaluated on Overall mortality at 12 months. Conservative management with pocket revision for CIED infections resulted in an 8.1% mortality rate at 12 months, with over two-thirds of patients remaining complication-free.
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