Key result
Omega-3 reduces BNP ~34% and modestly improves diastolic function in CHF patients.
Why the study?
Possible beneficial effects of dietary omega-3 supplementation on patients with congestive heart failure were investigated.
Does omega-3 supplementation improve BNP levels and echocardiographic parameters in patients with congestive heart failure?
RCT (n=70)
Double-blind
randomized
Does omega-3 supplementation improve BNP levels and echocardiographic parameters in patients with congestive heart failure?
Omega-3 supplementation in CHF patients with CRT-D devices leads to modest reductions in BNP and improvements in diastolic function, but does not significantly affect mortality or hospitalization rates.
Answers are grounded in this paper and cite their sources.
Omega-3 yielded modest BNP reduction and diastolic gains in CRT-D patients; extends biomarker data but leaves clinical outcome benefits open.
BACKGROUND: Possible beneficial effects of dietary omega-3 supplementation on patients with congestive heart failure (CHF) were investigated. METHODS AND RESULTS: 100 patients with CHF who had a tri-chamber pacemaker and automated defibrillator were initially recruited, and 70 agreed to participate.38 patients received 2 g/day of omega-3 and 32 received placebo capsules. BNP level, 6-min walk test and echocardiographic parameters were recorded at baseline and after 6 months of treatment. BNP levels decreased significantly after 6 months in the omega-3 group, from 1766.2 ± 1978.1 pg/mL to 1159.4 ± 1430.9 pg/dL (P < 0.005). Tei index and late diastolic velocity index were significantly improved in treated group. Mortality and hospitalization rates did not differ. CONCLUSION: The beneficial effects of omega-3 supplementation in patients with CHF were not as clear as hypothesized; however, omega-3 fatty acids can result in small changes in plasma BNP levels and modest improvements in echocardiographically assessed diastolic function (Clinical trial.gov registration: NCT01227837).
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Kojuri et al. (2013) conducted an RCT in congestive heart failure (n=70). omega-3 vs. placebo was evaluated on BNP level (p=< 0.005). Omega-3 supplementation (2 g/day) for 6 months in patients with CHF decreased BNP levels from 1766.2 to 1159.4 pg/dL and modestly improved diastolic function.
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