Key result
Male sex is linked to ~39% higher in-hospital mortality in hypertensive emergencies versus female sex.
Why the study?
Despite advances in treatment, gender disparities in outcomes of hypertensive emergency have not been addressed.
Does male sex increase the risk of all-cause inpatient mortality in patients admitted for hypertensive emergency?
Population
229,025 patients admitted for hypertensive emergency in the US National Inpatient Sample
Comparison
Male sex vs female sex
Design
Retrospective cohort study using nationally representative inpatient data
Follow-up
Inpatient stay
Authors
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May warrant sex-stratified risk assessment in hypertensive emergency; leaves open causal mechanisms and need for prospective confirmation.
Cohort (n=229,025)
Yes
Does male sex increase the risk of all-cause inpatient mortality in patients admitted for hypertensive emergency?
Odds Ratio: 1.39 (95% CI 1.02–1.91)
Absolute Event Rate: 0.4% vs 0.36%
p-value: p=0.036
Male patients admitted for hypertensive emergency have significantly higher odds of inpatient mortality compared to female patients, highlighting a critical gender disparity in outcomes.
Francis-Morel et al. (2023) conducted a cohort in Hypertensive emergency (n=229,025). Male sex vs. Female sex was evaluated on All-cause inpatient mortality (aOR 1.39, 95% CI 1.02-1.91, p=0.036). Male patients admitted for hypertensive emergency had 39% higher odds of in-hospital mortality compared to female patients.
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