Key result
Female sex links to ~38% lower mortality after ED discharge for hypertensive urgency.
Why the study?
Sex-related differences in all-cause mortality, cardiovascular mortality, and MACE after emergency department discharge for hypertensive urgencies had not been evaluated.
Does female sex reduce all-cause mortality and MACE in adults discharged from the emergency department for hypertensive urgencies?
Population
2,398 adults evaluated in the ED for hypertensive urgencies
Comparison
Female sex vs male sex
Design
Retrospective observational cohort study
Follow-up
At least one year
Authors
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Should not yet alter post-discharge care after hypertensive urgencies; observational association leaves causal inference open for prospective trials.
Cohort (n=2,398)
Does female sex reduce all-cause mortality and MACE in adults discharged from the emergency department for hypertensive urgencies?
Hazard Ratio: 0.62
p-value: p=0.004
Female sex is independently associated with lower all-cause mortality and a reduced risk of major cardiovascular events after emergency department discharge for hypertensive urgencies.
Paz et al. (2026) conducted a cohort in hypertensive urgencies (n=2,398). Female sex vs. Male sex was evaluated on all-cause mortality (HR 0.62, p=0.004). Female sex was independently associated with lower all-cause mortality (HR 0.62; p=0.004) and a reduced risk of MACE (HR 0.70; 95% CI 0.53-0.93) after ED discharge for hypertensive urgencies.
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