Key result
Very low nocturnal HR CV is linked to ~75% sudden death risk within two months.
Why the study?
Some ALS patients die suddenly despite normal nocturnal pulse oximetry, possibly due to dysautonomia, but predictors of sudden death are unclear.
Does decreased heart rate variability predict sudden death in patients with amyotrophic lateral sclerosis?
Comparison
Heart rate coefficient of variation during nocturnal sleep over time
Design
Cohort study
Authors
Loading...
May flag sudden death risk in ALS despite normal NPO; hypothesis-generating for nocturnal HR CV as prognostic marker.
Cohort (n=44)
Does decreased heart rate variability predict sudden death in patients with amyotrophic lateral sclerosis?
p-value: p=<0.01
Decreased heart rate variability during sleep may serve as a prognostic marker for sudden death in patients with amyotrophic lateral sclerosis.
Pinto et al. (2012) conducted a cohort in Amyotrophic lateral sclerosis (n=44). Low heart rate coefficient of variation (HR CV) was evaluated on Change in heart rate coefficient of variation (HR CV) at 24 months (p=<0.01). A significant decrease in heart rate coefficient of variation was observed at 24 months (P<0.01), and 3 of 4 patients with very low values (<0.20) died suddenly within 2 months.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: