Key result
Pulmonary metastasectomy shows no proven survival benefit over natural history for metastatic soft tissue sarcomas.
Why the study?
The impact of pulmonary metastasectomy on survival in metastatic soft tissue sarcomas is unclear due to lack of prospective studies with appropriate control groups.
Does pulmonary metastasectomy improve survival in patients with metastatic soft tissue sarcomas?
Population
Patients with metastatic soft tissue sarcomas
Comparison
Pulmonary metastasectomy versus natural history of the tumor
Design
Literature review of studies from 1978-1994
Follow-up
>5 years in some studies
Authors
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Insufficient controlled evidence supports pulmonary metastasectomy in soft tissue sarcoma; leaves open survival benefit and requires prospective trials.
Does pulmonary metastasectomy improve survival in patients with metastatic soft tissue sarcomas?
The available literature does not provide sufficient evidence to justify aggressive pulmonary metastasectomy for soft tissue sarcomas, highlighting the need for randomized prospective studies.
Daniel B. Frost (1995) conducted a review in Metastatic soft tissue sarcomas. Pulmonary metastasectomy was evaluated on Survival. Aggressive pulmonary metastasectomy for metastatic soft tissue sarcomas does not seem justified by available data, as survival benefits over the natural history of the tumor remain unproven.
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