Key result
First-year intimal thickness progression ≥0.5 mm linked to ~3.5-fold higher post-transplant death or graft loss.
Why the study?
Cardiac allograft vasculopathy is a major impediment to long-term graft survival, and the validity of first-year IVUS data as a surrogate marker for long-term outcome after heart transplantation was uncertain.
Does first-year progression of intimal thickness >=0.5 mm on IVUS predict long-term mortality and adverse events in heart transplant recipients?
Population
125 heart transplant recipients from five institutions
Comparison
First-year IVUS progression of maximal intimal thickness ≥0.5 mm vs <0.5 mm
Design
Multicenter cohort study with core lab IVUS re-analysis
Follow-up
Five years
Authors
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First-year progression of intimal thickening >=0.5 mm on IVUS is a reliable surrogate marker for 5-year mortality and adverse cardiac events after heart transplantation.
Cohort (n=125)
Yes
Does first-year progression of intimal thickness >=0.5 mm on IVUS predict long-term mortality and adverse events in heart transplant recipients?
Absolute Event Rate: 20.8% vs 5.9%
p-value: p=0.007
First-year progression of intimal thickening >=0.5 mm on IVUS is a reliable surrogate marker for 5-year mortality and adverse cardiac events after heart transplantation.
Kobashigawa et al. (2005) conducted a cohort in Heart transplant recipients (n=125). Progression of maximal intimal thickness ≥0.5 mm vs. Maximal intimal thickness <0.5 mm was evaluated on Death or graft loss (p=0.007). First-year progression of maximal intimal thickness ≥0.5 mm after heart transplantation was associated with higher death or graft loss compared to <0.5 mm (20.8% vs 5.9%; p=0.007).
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