Key result
First-trimester rubella, thalidomide, excessive vitamin D, and maternal phenylketonuria are linked to fetal cardiac defects.
Why the study?
Certain maternal exposures during pregnancy are known to cause congenital heart disease, but comprehensive understanding of all causative events is incomplete.
What events that occur during pregnancy can cause congenital heart disease?
What events that occur during pregnancy can cause congenital heart disease?
Highlights known teratogenic causes of congenital heart disease and emphasizes the importance of proper prenatal care and avoiding self-medication.
Answers are grounded in this paper and cite their sources.
May inform teratogen-avoidance counseling in pregnancy; leaves open need for updated prospective risk quantification.
What events that occur during pregnancy can cause congenital heart disease? Not all facts are in, but it is certain that first-trimester rubella, thalidomide ingestion, excessive vitamin D intake, and maternal phenylketonuria can lead to cardiac defects in the unborn infant. To help prevent defects, physicians should discourage self-medication, recommend proper doses of vitamins, and encourage good prenatal care.
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Catherine A. Neill (1968) conducted a review in Congenital heart disease. First-trimester rubella, thalidomide ingestion, excessive vitamin D intake, and maternal phenylketonuria was evaluated on Cardiac defects in the unborn infant. First-trimester rubella, thalidomide ingestion, excessive vitamin D intake, and maternal phenylketonuria are exposures during pregnancy that can lead to cardiac defects in the unborn infant.
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