Key result
Resecting both atrial appendages cuts furin levels ~84% during fluid overload in swine ischemic HF.
Why the study?
The impact of atrial appendage resection on natriuretic peptide production under volume overload conditions was not well understood.
Does resection of atrial appendages alter natriuretic peptide homeostasis during volume overload in a swine model of ischemic heart failure?
Does resection of atrial appendages alter natriuretic peptide homeostasis during volume overload in a swine model of ischemic heart failure?
Resection of atrial appendages in a swine model of ischemic heart failure significantly alters natriuretic peptide homeostasis, particularly blunting the furin response to fluid overload.
Answers are grounded in this paper and cite their sources.
Appendage resection blunts furin response to volume overload in swine HF; hypothesis-generating, leaves open human relevance and should not change practice.
BACKGROUND: The left atrial appendage (LAAp) resection is an effective treatment approach to reduce the risk of thromboembolism in patients with atrial fibrillation. OBJECTIVE: To study was to study the impact of removing atrial appendages in the production of natriuretic peptides (NPs) in conditions of volume overload and to develop an experimental model of LAAp resection. MATERIALS AND METHODS: In a swine model of ischemic heart failure (HF), serum NP levels were measured before (Basal-1A) and after (Basal-1B) a fluid overload. Animals were grouped as follows: (0) preserved appendages, (1) resected LAAp, and (2) both atrial appendages resected. Levels of NP were measured before (2A) and after a fluid overload (2B). RESULTS: Furin levels were higher in Group 0-2A than in Group 2-2A, and a significant increase was found in Group 0-2B compared to Groups 1-2B and 2-2B. Corin levels increased in Basal-1B versus Basal-1A. Atrial NP (ANP) decreased in Basal-1B compared to Basal-1A. After HF induction, ANP increased in Groups 2-2A and 2-2B. CONCLUSIONS: Resection of atrial appendages drastically modifies the natriuretic mechanisms of cardiac homeostasis, especially after a fluid overload challenge. Herein, we describe the face and predictive validation of an animal model of atrial appendage resection useful to investigations in translational medicine.
No takes yet. Share an insight, caveat, or question.
Márquez-Velasco et al. (2020) studied Ischemic heart failure (n=12). Resection of atrial appendages vs. Preserved atrial appendages was evaluated on Normalized serum furin levels after acute fluid overload during heart failure. Resection of both atrial appendages significantly decreased normalized furin levels (0.34 vs 2.07) compared to preserved appendages following an acute fluid overload challenge in a swine model of ischemic heart failure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: