Why the study?
Does surgical closure of the Left Atrial Appendage (LAA) reduce the increase of MR-proANP during exercise in patients undergoing planned cardiac surgery?
Does surgical closure of the Left Atrial Appendage (LAA) reduce the increase of MR-proANP during exercise in patients undergoing planned cardiac surgery?
Surgical closure of the left atrial appendage does not eliminate the exercise-induced rise in MR-proANP, suggesting alternative sources or mechanisms of ANP secretion.
LAA closure does not blunt exercise-induced MR-proANP release; challenges prior assumptions on LAA's dominant role in stress ANP secretion.
The atrial appendages play a regulatory role in the fluid homeostasis and in the secretion of atrial natriuretic peptide (ANP). ANP is a 28-amino-acid peptide synthesized in the cardiac myocytes, where it is stored as a pro-hormone in cardiomyocyte granules. When released, it participates in cardiovascular volume and pressure homeostasis. We hypothesized that patients with surgical closure of the Left Atrial Appendage (LAA) -would have lower increase of Mid Region-pro-hormone ANP (MR-proANP) during exercise compared to patients with open LAA. Patients were randomized into two groups -one with surgical closure of the LAA during planned cardiac surgery and one with open LAA.
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Jesper Park Hansen (2017) studied this question.
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