Key result
Review evaluates DAPT type and duration for ischemic and bleeding outcomes in complex PCI.
Why the study?
Antiplatelet therapy in complex PCI patients remains controversial due to the balance between reducing ischemic complications and increasing bleeding risk with potent agents or prolonged DAPT.
How do different types and durations of dual antiplatelet therapy affect ischemic and bleeding outcomes in patients undergoing complex PCI?
How do different types and durations of dual antiplatelet therapy affect ischemic and bleeding outcomes in patients undergoing complex PCI?
This review highlights the need to carefully balance ischemic benefits against bleeding risks when tailoring the type and duration of DAPT for high-risk patients undergoing complex PCI.
Urges risk-benefit balancing for DAPT in complex PCI; leaves open optimal regimens for prospective trials.
Complex percutaneous coronary intervention (PCI) patients are a high-risk population for ischemic complications. Antiplatelet therapy in such patients remains controversial, as the beneficial effects of the use of more potent agents or prolonged dual antiplatelet treatment (DAPT) on atherothrombotic complications are hindered by a concomitant increase in bleeding rates. The aim of this article is to describe ischemic and bleeding outcomes associated with complex PCI procedures and to compare different types and durations of DAPT regimens in terms of safety and efficacy outcomes. Issues concerning special patient groups, such as those with left main, chronic total occlusion, or bifurcation lesions, are discussed.
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Alexopoulos et al. (2020) conducted a review in Complex percutaneous coronary intervention (PCI). Dual antiplatelet therapy (DAPT) was evaluated. Dual antiplatelet therapy type and duration in complex percutaneous coronary intervention are reviewed regarding ischemic and bleeding outcomes.
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