Key result
Cytosolic calcium elevations driven by altered autonomic control can trigger ventricular fibrillation.
Why the study?
Alterations in cardiac autonomic control causing changes in cytosolic second messenger concentrations may underlie the cellular mechanisms of malignant arrhythmias such as ventricular fibrillation.
Design
Review
Authors
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May link autonomic changes to VF via calcium; leaves open clinical translation of targeted interventions.
Highlights the role of cytosolic calcium elevations in altering cardiac impulse generation and conduction as a cellular mechanism for ventricular fibrillation.
GE Billmann (1992) conducted a review in Ventricular Fibrillation. Cytosolic calcium elevations was evaluated on Ventricular fibrillation. Cytosolic calcium elevations, driven by alterations in cardiac autonomic control, can alter cardiac impulse generation and conduction to trigger ventricular fibrillation.
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