Key result
Human bocavirus 2 detection is ~66% higher in children with gastroenteritis compared to asymptomatic controls.
Why the study?
The precise phylogenetic relationships among human bocavirus species including HBoV2, HBoV3, and HBoV4 are not clear.
Case-Control (n=794)
Answers are grounded in this paper and cite their sources.
Phylogenetic analysis suggests HBoV3 may be a recombinant between HBoV and the common ancestor of HBoV2 and HBoV4.
BACKGROUND: Human bocavirus 2(HBoV2) and other human bocavirus species (HBoV, HBoV3, and HBoV4) have been discovered recently. But the precise phylogenetic relationships among these viruses are not clear yet. METHODS: We collected 632 diarrhea and 162 healthy children in Lanzhou, China. Using PCR, Human bocavirus (HBoV), HBoV2, HBoV3 and HBoV4 were screened. The partial genes of NS, NP1 and VP, and two nearly complete sequences of HBoV2 were obtained. RESULT: Phylogenetic analysis showed the different genes of HBoV2 strain were homogenous with different reference strains. HBoV3 may be a recombinant derived from HBoV and HBoV4. We also observed that the VP1 and VP2 region of HBoV3 is as similar to HBoV2 as to HBoV4. CONCLUSIONS: A single genetic lineage of HBoV2 is circulating in children with and without gastroenteritis in Lanzhou, China. Current evidence in this study was not enough to support recombination between HBoV2 strains, and HBoV3 may be a recombinant between HBoV and the common ancestor of HBoV2 and HBoV4.
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Cheng et al. (2011) conducted a case-control in Gastroenteritis (n=794). Human bocavirus 2 (HBoV2) vs. Asymptomatic controls was evaluated on Prevalence of HBoV2. Human bocavirus 2 was detected in 20.4% of children with gastroenteritis and 12.3% of asymptomatic controls, with a single genetic lineage circulating in both groups.
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