Population
7 subjects
Design
Other
Follow-up
2-hr infusion plus postinfusion period
Key result
Intravenous infusion of ethyl alcohol demonstrated Michaelis-Menten elimination kinetics with an average Vm of 0.232 mg/(ml x hr) and Km of 0.0821 mg/ml.
Authors
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Offers precise IV alcohol PK parameters for modeling; leaves open clinical translation pending higher-level validation.
The study defines the time course of blood ethanol concentrations during and after IV infusion, showing elimination kinetics consistent with oral administration.
Wilkinson et al. (1976) studied this question. Intravenous infusion of ethyl alcohol was evaluated on Pharmacokinetic parameters (Vm and Km) for ethanol elimination. Intravenous infusion of ethyl alcohol demonstrated Michaelis-Menten elimination kinetics with an average Vm of 0.232 mg/(ml x hr) and Km of 0.0821 mg/ml.
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