Key result
Non-insulin dependent diabetes under five years is associated with LVDD in ~61% of patients.
Why the study?
Left ventricular diastolic dysfunction is a prevalent condition among patients with non-insulin dependent diabetes mellitus, but its frequency in this population was not well defined.
Cross-Sectional (n=114)
No
A high prevalence of left ventricular diastolic dysfunction (61.4%) is present in patients with non-insulin dependent diabetes mellitus of less than 5 years duration, even in the absence of overt cardiovascular disease.
Objectives: Left ventricular diastolic dysfunction (LVDD) is a prevalent condition among patients with non-insulin dependent diabetes mellitus (NIDDM). The aim of this study was to determine the frequency of the LVDD in patients with NIDDM at a tertiary care cardiac center of Karachi, Pakistan. Methodology: This descriptive cross-sectional study included NIDDM patients without history of ischemic heart disease, on anti-hypertensive medication, diagnosed with valvular heart disease, congenital heart disease, arrhythmias, chronic respiratory illness, or with clinically overt heart failure (HF) or history of HF or concomitant systolic dysfunction. Transthoracic echocardiography was performed and LVDD was diagnosed. Results: A total of 114 patients with NIDDM of less than five years were included in this study. Most of the patients were 41 to 60 years of age with mean age of the 52.23±10.85 years. Out of 114 cases, 58(50.9%) were male. Frequency of LVDD was observed to be 61.4% (70/114). With respect to age groups, rate of LVDD was high in above 60 years of age patients that is 90% (18/20) and it was observed 64.9% (24/37) in 51 to 60 years of age. Rate of LVDD was also high in male patients than female with frequency of 70.7% (41/58) vs. 51.8% (29/56). Conclusion: A significant number of patients with NIDDM were found to have LVDD. Increased frequency of LVDD was observed to be associated with male gender and increased age of the patients.
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Soomro et al. (2022) conducted a cross-sectional in Non-insulin dependent diabetes mellitus (NIDDM) (n=114). Non-insulin dependent diabetes mellitus was evaluated on Frequency of left ventricular diastolic dysfunction (LVDD). Left ventricular diastolic dysfunction was present in 61.4% of patients with non-insulin dependent diabetes mellitus for less than five years, with a significantly higher prevalence in males and older individuals.
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