Key result
320-CTCA at elevated heart rates yields comparable diagnostic accuracy to rates under 60 bpm.
Why the study?
The impact of elevated heart rate on the diagnostic accuracy and image quality of second-generation 320-detector CT coronary angiography was unclear.
Does elevated heart rate (61-80 bpm) reduce the diagnostic accuracy of second-generation 320-detector CTCA compared to traditional heart rate (≤60 bpm) in patients with suspected coronary disease?
Population
107 consecutive patients with suspected coronary disease referred for invasive coronary angiography
Comparison
320-CTCA at HR ≤60 bpm vs 320-CTCA at HR 61–80 bpm with wider phase window
Design
Prospective cohort with independent blinded readers
Authors
Loading...
Second-generation 320-CTCA maintains accuracy at HR 61–80 bpm; supports reduced beta-blocker reliance but leaves practice change open pending randomized confirmation.
Observational (n=107)
Blinded readers
Does elevated heart rate (61-80 bpm) reduce the diagnostic accuracy of second-generation 320-detector CTCA compared to traditional heart rate (≤60 bpm) in patients with suspected coronary disease?
Absolute Event Rate: 0.94% vs 0.93%
p-value: p=0.82
Second-generation 320-detector CTCA provides comparable diagnostic accuracy in patients with heart rates up to 80 bpm compared to those with heart rates ≤60 bpm, without significantly increasing uninterpretable segments.
Nerlekar et al. (2017) conducted an observational in Suspected coronary disease (n=107). Elevated heart rate (61-80 bpm) vs. Heart rate ≤60 bpm was evaluated on Receiver operator characteristic-area under the curve (ROC-AUC) (p=0.82). In patients undergoing 320-CTCA, elevated heart rate (61-80 bpm) provided comparable diagnostic accuracy to heart rate ≤60 bpm (ROC-AUC 0.94 vs 0.93, P=0.82).
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: