Key result
RAAS provides essential homeostatic control of BP, fluid, and electrolyte balance.
Why the study?
The renin–angiotensin–aldosterone system is essential for blood pressure and fluid balance regulation, warranting a comprehensive review of renin's role.
Key points are not available for this paper at this time.
Design
Review article
Underpins RAAS inhibitor use in hypertension and HF; leaves open optimization in resistant or variant phenotypes.
IN 1898 Tigerstedt and Bergman1 observed a sustained pressor response after the infusion of a saline extract of renal tissue into a rabbit. This ultimately led to elucidation of the renin–angiotensin–aldosterone system, the components of which are essential for homeostatic control of blood pressure and fluid and electrolyte balance. The aspartyl proteinase renin is released from juxtaglomerular cells encircling the afferent arterioles in the kidney. It acts on the α2-globulin angiotensinogen, produced in the liver, to form the nonpressor decapeptide angiotensin I. This in turn is cleaved by the peptidyl dipeptidase angiotensin-converting enzyme to angiotensin II, which has . . .
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Kem et al. (1990) reported a review. The renin-angiotensin-aldosterone system is essential for the homeostatic control of blood pressure and fluid and electrolyte balance.
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