Key result
BPH and prostate cancer associate with higher oxidative stress and homocysteine but not vitamin B12.
Why the study?
Oxidative stress and one carbon metabolism are important contributory factors in the etiopathogenesis of prostate neoplasm, but their comparative levels in patients versus controls require review.
Do oxidative stress and one carbon metabolism markers differ between patients with prostate neoplasm and controls?
Do oxidative stress and one carbon metabolism markers differ between patients with prostate neoplasm and controls?
Oxidative stress and elevated homocysteine levels are associated with prostate neoplasms, suggesting a potential role for antioxidant therapies.
Elevated homocysteine and oxidative stress may associate with prostate disease; hypothesis-generating and should not change practice.
Carcinoma of the prostate is the most common malignant tumour in men over the age of 65 years with peak age of incidence between 70 and 74 years. Oxidative stress and one carbon metabolism are important contributary factors in etiopathogenesis in Prostate Neoplasm. Significant increase in oxidative stress and serum homocysteine level and no difference of serum vitamin B12 was found in BPH and prostate cancer cases compared to control group. Following review compare level of Oxidative Stress Marker and One Carbon Metabolism markers between Prostate neoplasm patients and control Group. Antioxidant drugs may play a role in influencing outcome in these patients. However, randomized trials are required to investigate.
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Kumari et al. (2023) conducted a review in Prostate Neoplasm. Oxidative stress and one carbon metabolism vs. Control group was evaluated on Levels of oxidative stress markers and one carbon metabolism markers (homocysteine, vitamin B12). Oxidative stress and serum homocysteine levels were significantly increased in BPH and prostate cancer cases compared to controls, with no difference in serum vitamin B12.
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