What question did this study set out to answer?

To evaluate predictors of progression from normal glucose tolerance to glucose intolerance over a 5-year period.

December 31, 2025Diabetes Research and Clinical PracticeOpen Access

Simultaneous assessment of one-hour plasma glucose levels and age as a potential predictor of glucose intolerance development in individuals with normal glucose tolerance

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To evaluate predictors of progression from normal glucose tolerance to glucose intolerance over a 5-year period.
Conducted a 5-year prospective cohort study of 1,008 Japanese individuals with baseline normal glucose tolerance.
Diagnosed glucose intolerance using a standard 75-g oral glucose tolerance test and evaluated predictors using multivariable logistic regression.
Assessed type 2 diabetes susceptibility via single-nucleotide polymorphism analysis.
Identified an interaction between 1-hour plasma glucose levels and age as a key predictor of progression to glucose intolerance.
Participants with 1-hour plasma glucose ≥ 8.3 mmol/L and age ≥ 57 years had a significantly higher risk of developing glucose intolerance (adjusted OR 12.9; 95% CI: 5.7–29.2) relative to the reference group.
Genetic risk variants for type 2 diabetes were associated with elevated 1-hour plasma glucose concentrations.

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Implication

Prospective cohort study reveals combined one-hour glucose levels and age strongly predict glucose intolerance in healthy adults, highlighting opportunities for earlier risk stratification.

Cite This Study

Takakado et al. (2025) studied this question.

synapsesocial.com/papers/6aae332f8f728e8281adbc59 https://doi.org/10.1016/j.diabres.2025.113079

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Implication

Prospective cohort study reveals combined one-hour glucose levels and age strongly predict glucose intolerance in healthy adults, highlighting opportunities for earlier risk stratification.

Simultaneous assessment of one-hour plasma glucose levels and age as a potential predictor of glucose intolerance development in individuals with normal glucose tolerance

Key Points

Discussion

Implication

Cite This Study

Simultaneous assessment of one-hour plasma glucose levels and age as a potential predictor of glucose intolerance development in individuals with normal glucose tolerance

Key Points

Discussion

Implication

Cite This Study

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