Key result
Age over 75 shows no increased early complication risk versus younger patients in colorectal cancer surgery.
Why the study?
Advanced age in patients with colorectal cancer appears to increase the risk of postoperative complications, but this relationship requires clarification.
Does advanced age (>75 years) increase the risk of early postoperative complications in patients undergoing elective colorectal cancer surgery compared to younger patients?
Cohort (n=440)
No
Does advanced age (>75 years) increase the risk of early postoperative complications in patients undergoing elective colorectal cancer surgery compared to younger patients?
Absolute Event Rate: 21.1% vs 19.9%
Age itself is not a risk factor for early postoperative complications in elective colorectal cancer surgery, despite a higher prevalence of comorbidities in older patients.
Does not support age-based exclusion from elective colorectal cancer surgery; leaves open prospective confirmation in broader cohorts.
UNLABELLED: Colorectal cancer is the most common malignant neoplasm in elderly with peak of incidence in 7. and 8. decade of life. Elderly patients with colorectal cancer more often require surgery. Advanced age of patients seems to increase the risk of postoperative complications. The aim of the study was to compare the frequency of early complications in two groups of patients: under 75 and over 75, undergoing elective colorectal cancer surgery. MATERIAL AND METHODS: 440 consecutive adult patients subjected to colorectal cancer surgery between 08.2006 to 10.2011 in Oncological Surgery Department, Gdynia Centre of Oncology. Group A (over 75 year-of-life): 109 patients, median 79 and group B (up to 75 year-of-life): 331 patients, median 65. Patients requiring emergency surgery were excluded from the study. Postoperative 30-day mortality, anastomotic leakage, wound infection, bowel obstruction, postoperative respiratory and circulatory insufficiency were among analyzed complications. RESULTS: Symptomatic disease was observed in 81.6% of group A and in 83% of group B. Groups A and B were comparable concerning: BMI, gender, tumor staging, rate of curative and palliative resections, and duration of hospital stay. Accompanying diseases were more common in group A (83% vs 65%; p<0.0002). Early complications occurred in 21.1% of patients from group A and in 19.9% from group B. The rate of reoperation in early perioperative period didn't differ (6.4% vs 5.7%). Features like: age, gender, additional illnesses, tumor location and staging did not influence the occurrence of perioperative complications. CONCLUSIONS: Age itself is not a risk factor for postoperative complications in spite of higher rate of accompanying diseases in elderly.
No takes yet. Share an insight, caveat, or question.
Wydra et al. (2013) conducted a cohort in colorectal cancer (n=440). Age over 75 years vs. Age up to 75 years was evaluated on Early postoperative complications. Age over 75 years did not increase the risk of early postoperative complications compared to age up to 75 years (21.1% vs 19.9%) following elective colorectal cancer surgery.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: