Key result
High-cholesterol diet depresses vasoconstrictor response to noradrenaline in rabbit arteries vs regular diet.
Why the study?
The effect of a high-cholesterol atherogenic diet on the in vitro responsiveness of rabbit arterial smooth muscle to noradrenaline was investigated.
Does a high-cholesterol diet alter the responsiveness of rabbit arterial smooth muscle to noradrenaline?
Does a high-cholesterol diet alter the responsiveness of rabbit arterial smooth muscle to noradrenaline?
A high-cholesterol diet significantly depresses the vasoconstrictor response of rabbit arterial smooth muscle to noradrenaline in a preclinical model.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating in rabbits; does not support clinical changes in hypercholesterolemia management.
The potential effect of feeding a high-cholesterol atherogenic diet (HCD) on in vitro responsiveness of rabbit arterial smooth muscle was investigated. The vasoconstrictor response produced by either exogenous or endogenous (field stimulation) noradrenaline was significantly depressed in isolated segments of ear artery after HCD as compared to regular diet fed animals. On the other hand no changes to high K+ could be observed in arterial segments after HCD as compared to regular diet fed rabbits. In addition, the alpha-adrenoceptor-mediated inotropic response and contraction of bladder smooth muscle showed only minor or no changes after HCD as compared to regular diet fed rabbits.
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Maggi et al. (2008) studied this question. High-cholesterol atherogenic diet (HCD) vs. Regular diet was evaluated on In vitro responsiveness of rabbit arterial smooth muscle to noradrenaline. A high-cholesterol diet significantly depressed the vasoconstrictor response of isolated rabbit ear artery segments to exogenous or endogenous noradrenaline compared to a regular diet.
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