Key result
Review outlines the advantages and limitations of various RCT designs in stroke research.
Why the study?
Randomized clinical trials are considered the most rigorous design to determine intervention efficacy by avoiding spurious causality and bias, but the types and their advantages and limitations in stroke research need clarification.
This article reviews the types, advantages, and limitations of randomized clinical trials used in stroke research.
May inform RCT design selection in stroke research; leaves open which approach optimizes validity and feasibility.
A randomized clinical trial is widely regarded as the most rigorous study design to determine the efficacy of intervention because spurious causality and bias associated with other experimental designs can be avoided. The purpose of this article is to provide clinicians and clinical researchers the types of randomized clinical trials used in stroke studies and to discuss the advantages and the limitations for each type of randomized stroke clinical trials.
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Ahn et al. (2010) conducted a review in Stroke. This article reviews the types of randomized clinical trials used in stroke studies, discussing the advantages and limitations of each design for clinicians and researchers.
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