Key result
Early hip fracture surgery on clopidogrel shows similar bleeding and transfusion rates vs no clopidogrel.
Why the study?
The safety of early hip fracture surgery without the standard 5-7 days waiting time after clopidogrel discontinuation in elderly patients was uncertain.
Does early hip fracture surgery without a 5-7 day waiting period increase bleeding risk in elderly patients on long-term clopidogrel compared to those not on clopidogrel?
Population
Elderly patients over 65 years with fresh hip fracture
Comparison
Early surgery without 5-7 days waiting after clopidogrel vs surgery without clopidogrel
Design
Retrospective cohort study
Authors
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Early hip fracture surgery on clopidogrel may not raise bleeding risk in elderly patients; leaves open need for prospective trials before practice change.
Cohort
Does early hip fracture surgery without a 5-7 day waiting period increase bleeding risk in elderly patients on long-term clopidogrel compared to those not on clopidogrel?
Early hip fracture surgery in elderly patients on long-term clopidogrel without a 5-7 day washout period appears safe and does not significantly increase bleeding risk compared to patients not on clopidogrel.
Zheng et al. (2021) conducted a cohort in Hip fracture. Clopidogrel vs. No clopidogrel was evaluated on Bleeding outcomes (intraoperative blood loss and blood transfusion status). Early hip fracture surgery in elderly patients taking clopidogrel resulted in similar intraoperative blood loss and blood transfusion rates compared to patients without clopidogrel.
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