Key result
Optimizing atrial lead location and AV timing boosts cardiac output ~21% in dogs with AV block.
Why the study?
The combined role of atrial pacing lead location and AV timing on cardiovascular performance has not been defined.
Does atrial pacing lead location alter the effects of AV delay on atrial and ventricular hemodynamics in dogs with AV block?
Population
8 isoflurane-anesthetized dogs with AV node ablation
Comparison
Dual chamber pacing from RAA, CS, and LAW at various AV delays vs normal sinus rhythm and atrial overdrive pacing
Design
Preclinical experimental study
Authors
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May influence AV pacing optimization in block; leaves open translation to human lead placement.
Does atrial pacing lead location alter the effects of AV delay on atrial and ventricular hemodynamics in dogs with AV block?
Absolute Event Rate: 3.5% vs 2.9%
p-value: p=< 0.05
The atrial contribution to cardiac output depends on both AV timing and atrial lead location in a canine model with AV block.
Hettrick et al. (2002) studied AV nodal conduction block (n=8). Atrial pacing lead location and AV timing vs. Intrinsic sinus rhythm and overdrive atrial pacing was evaluated on Cardiac output (p=< 0.05). Atrial pacing lead location and AV timing significantly altered cardiac output in dogs with AV block, with right atrial appendage pacing yielding 3.5 L/min at 120 ms vs 2.9 L/min at 350 ms (P<0.05).
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