Key result
Peak PPV2 antibodies coincide with resolving respiratory signs, suggesting a role in respiratory disease.
Why the study?
Porcine parvovirus 2 is frequently detected in lung samples and may have a pathological role in respiratory diseases in swine, but its serological profile and clinical impact are not well characterized.
Observational (n=185)
No
The correlation between changes in virus load, antibody levels, and the onset and decrease of clinical signs suggests that PPV2 may play a role in the development of respiratory signs in swine.
Association of PPV2 seroconversion with respiratory sign resolution in swine is hypothesis-generating; leaves open causality and precludes clinical translation.
Porcine parvovirus 2 (PPV2) is a member of a recently discovered group of swine parvoviruses occurring worldwide. It is frequently detected in lung samples suggesting some pathological role of the virus in diseases. To study this possibility an indirect ELISA was developed to detect PPV2 specific antibodies and to examine the serological profile of an infected swine herd where 185 serum samples collected from different age groups including sows were analyzed. According to the results maternal antibody levels decreased until 14 days of age and PPV2 specific antibodies started to rise between 28 to 43 days of age when respiratory signs were also observed in the examined swine herd. At 57 days of age the clinical signs disappeared and a rapid increase of PPV2 specific antibody levels could be measured simultaneously, peaking at 57 days of age. The viraemic status of different age groups was determined by qPCR using serum samples. At least a low level of viraemia was measured in every age group, but higher copy number of PPV2 was only detected at 57 days of age and the level decreased in older age groups. The changes in virus load and antibody levels together with the onset and decrease of clinical signs suggested that PPV2 had a role in the development of respiratory signs.
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Cságola et al. (2016) conducted an observational in Porcine Parvovirus 2 (PPV2) infection (n=185). Porcine Parvovirus 2 (PPV2) infection vs. Different age groups was evaluated on PPV2 specific antibody levels and viraemia. PPV2 specific antibodies started to rise between 28 to 43 days of age and peaked at 57 days, coinciding with the disappearance of respiratory signs and suggesting a role for PPV2 in respiratory disease.
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