Lymphangioleiomyomatosis

Although the diagnosis of tuberous sclerosis complex-lymphangioleiomyomatosis (TSC-LAM) is rare in adolescents, emerging data suggest that its true incidence, particularly among females with TSC, may be underestimated. High-resolution CT of the chest is critical for identifying characteristic pulmonary cysts, while abdominal imaging plays a supportive role by detecting associated renal angiomyolipomas. Given the progressive nature of LAM, early recognition is essential for guiding management and improving outcomes. Clinicians should maintain a high index of suspicion for LAM in adolescents with TSC2 gene mutations.