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April 14, 2026Journal of Psychiatry SpectrumOpen Access

Platelet and Inflammatory Hematological Markers in Persons Who Attempt Suicide: A Hospital-based Case–Control Study

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Authors

MDMansoor Ahmad DarBBBilal Ahmad BhatSDShabir Ahmad Dar

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Overview

Case-control study observes elevated inflammatory markers in individuals attempting suicide, highlighting biological immune involvement.

Key Points

  • To evaluate hematological inflammatory markers in individuals who recently attempted suicide and analyze their associations with depression severity and suicidal intent.
  • Hospital-based case-control study matching 100 individuals aged 18–60 years with a recent suicide attempt to 100 age- and gender-matched healthy controls.
  • Psychiatric evaluation performed using DSM-5-TR, Beck Depression Inventory (BDI), Beck Suicide Intent (BSI) Scale, and Presumptive Stressful Life Events Scale.
  • Complete blood count parameters compared via Mann–Whitney U-test, with correlations analyzed using Spearman’s rank correlation.
  • Compared to controls, suicide attempters showed significantly higher mean platelet volume, neutrophil count, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio (all P < 0.001).
  • Suicide attempters had significantly lower lymphocyte counts and platelet counts compared to controls (both P < 0.001).
  • BDI scores inversely correlated with platelet count (P = 0.004), mean platelet volume (P = 0.005), neutrophil count (P < 0.001), and platelet-to-lymphocyte ratio (P < 0.001), while BSI scores positively correlated with lymphocyte and platelet counts (both P < 0.001).

Cite This Study

Dar et al. (2026) studied this question.

synapsesocial.com/papers/6aaf2c35ec6de5f9fc3983a3https://doi.org/10.4103/jopsys.jopsys_200_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The relationship between suicidal behavior and hematological inflammatory parameters: a retrospective cohort study2026
  2. 2High-lethality of suicide attempts associated with platelet to lymphocyte ratio and mean platelet volume in psychiatric inpatient setting2020 · 44 citations
  3. 3Correlates of Mean Platelet Volume and Psychosocial factors in cases of Attempted Suicide: Study from a Rural Medical College of Central India2024
  4. 4Evaluation of inflammatory parameters in patients who attempted suicide by taking drugs2022 · 6 citations
  5. 5Composite Inflammatory Burden and Suicide Risk: The Predictive Role of SII, SIRI, and PIV in Patients with Major Depressive Disorder2026