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December 30, 2024Indian Journal of Psychological MedicineOpen Access

Patients with depression had significantly higher MPV levels (p < .05) compared to those without depression, and there was a significant positive correlation between the severity of depression (p < .001) and the level of suicidal intent (p < .05).

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Why the study?

Depression is linked to increased platelet activity, but changes in mean platelet volume among individuals with attempted suicide had not been well-studied in the Indian setup.

Is there a relationship between clinical and psychosocial factors and mean platelet volume in individuals with attempted suicide?

Population

150 consecutive referrals of suicide attempt cases to a psychiatry outpatient department

Design

Hospital-based descriptive observational cross-sectional study

Authors

KMKshirod K. MishraPBPawar Gaurav B.

Discussion

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Overview

Depression-linked MPV rise in attempters should not change practice; leaves open biomarker hypothesis for prospective validation.

Structured PICO

Is there a relationship between clinical and psychosocial factors and mean platelet volume in individuals with attempted suicide?

P
Population
150 consecutive referrals of suicide attempt cases to a psychiatry outpatient department in a rural medical college in Central India, 70% male.
O
Outcome
Relationship between clinical and psychosocial factors and mean platelet volume (MPV)surrogate

In individuals who attempted suicide, the presence of depression is associated with significantly higher mean platelet volume, suggesting a link between depression and increased platelet activity.

Cite This Study

Mishra et al. (2024) studied this question.

synapsesocial.com/papers/6a1d2cd0102421609404f89ehttps://doi.org/10.1177/02537176241298999
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A study of leukocyte and platelet activity in patients with suicide attempt related to acute stres reaction2013 · 1 citations
  2. 2Platelet Serotonin Level and Impulsivity in Human Self-destructive Behavior: A Biological and Psychological Study2017 · 10 citations
  3. 3Mean platelet volume and neutrophil to lymphocyte ratio as parameters to indicate the severity of suicide attempt2018 · 47 citations
  4. 4Biochemical predictors in presentations to the emergency department after a suicide attemp2021 · 17 citations
  5. 5Composite Inflammatory Burden and Suicide Risk: The Predictive Role of SII, SIRI, and PIV in Patients with Major Depressive Disorder2026