Key result
Growth hormone increases red cell mass by ~183 mL in adults with GH deficiency.
Why the study?
It is unknown whether growth hormone regulates red cell mass and total blood volume in adults with growth hormone deficiency.
Does growth hormone increase red cell mass and plasma volume in adults with growth hormone deficiency?
Population
13 adult patients with growth hormone deficiency
Comparison
Growth hormone 0.036 U/kg.day vs placebo
Design
3-month double-blind placebo-controlled trial
Follow-up
3 months
Authors
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Supports vigilance for volume expansion during GH replacement; confirms direct hematologic effects in RCT.
RCT (n=13)
Double-blind
Does growth hormone increase red cell mass and plasma volume in adults with growth hormone deficiency?
Mean Difference: 183
p-value: p=<0.006
Growth hormone treatment in adults with GH deficiency significantly increases red cell mass, plasma volume, and total blood volume.
Emanuel Christ (1997) conducted an RCT in Growth hormone deficiency (n=13). Growth hormone vs. Placebo was evaluated on Red cell mass (RCM) (Mean increase 183 mL, p=<0.006). Growth hormone treatment for 3 months significantly increased red cell mass by 183 mL (P<0.006) and total blood volume by 515 mL (P<0.004) in adults with growth hormone deficiency.
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