Key result
High ADS score linked to ~103% greater all-cause mortality risk vs low score post-PCI.
Why the study?
The relationship between the novel ADS score and outcomes in coronary artery disease patients after PCI had not been investigated.
Does a high ADS score predict adverse clinical outcomes in CAD patients who underwent PCI?
Cohort (n=3,561)
No
Does a high ADS score predict adverse clinical outcomes in CAD patients who underwent PCI?
A high ADS score (≥ 2) is an independent predictor of long-term all-cause mortality, cardiac mortality, and MACCE in CAD patients following PCI.
Answers are grounded in this paper and cite their sources.
May inform post-PCI risk stratification in CAD; leaves open incremental value over existing scores.
Objectives: A novel AFR– albumin-derived neutrophil to lymphocyte ratio (dNLR) score (ADS) were reported to associate with clinical outcome in various malignancies, However, the relation between the ADS score and outcomes in coronary artery disease (CAD) patients after percutaneous coronary intervention (PCI) has not been investigated. Methods: Three thousand five hundred and sixty-one patients were divided into two groups according to ADS score: low group (ADS score <2; n = 2,682) and high group (ADS score ≥ 2; n = 879). Overall, there were 133 all-cause mortality (ACM) during the following up. The incidence of ACM in the low group is 2.7% (72/2,682) and high group is 6.9% (61/879). The ACM incidence was significantly higher in high group compared to that in the low group (P < 0.001). Cardiac mortality (CM) occurred in 82 patients: 44(1.6%) in the low group and 38 (4.3%) in the high group. There was significant difference in the CM incidence between the low group and high group (P < 0.001). Major adverse cardiac and cerebrovascular events (MACCE) occurred in 520 patients: 366 (13.6%) in the low group and 154 (17.5%) in the high group. There was significant difference in the MACCE incidence between the low group and high group (P = 0.005). Major adverse cardiac and events (MACE) occurred in 395 patients: 281(10.5%) in the low group and 114 (13.0%) in the high group. There was significant difference in the MACE incidence between the low group and high group (P = 0.041). The multivariate Cox proportional hazards model showed that ADS score was independently correlated with the ACM [adjusted HR = 2.031 (1.357–3.039), P = 0.001]; CM [adjusted HR = 1.883 (1.127–3.147), P = 0.016]; MACCE [adjusted HR = 1.352 (1.096–1.668), P = 0.005], and MACE [adjusted HR = 1.260 (0.987–1.608), P = 0.063]. Conclusion: The present study indicated that the ADS score was associated with long-term mortality, the MACCE, and the MACE in CAD patients underwent PCI.
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Zhang et al. (2021) conducted a cohort in Coronary artery disease (CAD) after percutaneous coronary intervention (PCI) (n=3,561). High ADS score (≥ 2) vs. Low ADS score (< 2) was evaluated on All-cause mortality (ACM) (HR 2.031, 95% CI 1.357-3.039, p=0.001). A high ADS score (≥ 2) was independently associated with a significantly increased risk of all-cause mortality compared to a low ADS score (HR 2.031) in patients with coronary artery disease who underwent PCI.
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