SIADH as the first symptom of Guillain–Barre syndrome

This is the authors' abstract. We don't add key points for this paper.

The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is observed in up to 26% of patients with Guillain–Barre syndrome (GBS), usually at the time of maximal motor deficit.1 SIADH is characterized by fluid retention leading to decreased sodium concentration and serum osmolality. We report a case of GBS with SIADH clearly preceding the evolution of paresis, paresthesia, and areflexia. A 38-year-old woman was referred to our hospital because of severe headaches and mild confusion that had developed 5 days after a gastrointestinal infection. Neurologic examination on admission was unremarkable except for a marked weariness and reduced vibration sense at the toes (3/8). The latter finding was related to Type I diabetes mellitus diagnosed 20 years before. CT and angiogram (to exclude dural sinus thrombosis) were normal. CSF revealed 8 cells/μL, mostly lymphocytes, …