Key result
Fentanyl shows no difference versus isoflurane in hormone and cytokine changes after cholecystectomy.
Why the study?
The impact of anesthesia mode on endocrine and immunologic stress response after open or laparoscopic cholecystectomy was unclear.
Does fentanyl anesthesia compared to isoflurane anesthesia alter the endocrine or immunologic profile in patients undergoing open or laparoscopic cholecystectomy?
Observational (n=46)
Does fentanyl anesthesia compared to isoflurane anesthesia alter the endocrine or immunologic profile in patients undergoing open or laparoscopic cholecystectomy?
The choice between fentanyl and isoflurane anesthesia does not significantly impact the immunoendocrine stress response following cholecystectomy.
Small observational data suggest anesthesia modulates postoperative stress markers; leaves open clinical relevance.
To verify the impact on stress response and the influence of anesthesia on endocrine/immunologic changes, we have investigated the plasma level of norepinephrine, cortisol, TNFalpha, and IL-6 in 46 patients scheduled for laparotomy and laparoscopic cholecystectomy at 2, 6, 12, and 24 h after the operation. Among subjects who underwent open approach, 9 received fentanyl anesthesia and 13 received isoflurane anesthesia. In the laparoscopy group, 14 patients were given fentanyl anesthesia and 10 were given isoflurane anesthesia. The results obtained confirmed that laparoscopic cholecystectomy is associated with a lesser immunoendocrine response, and the two anesthesia models do not interfere with plasma changes of the assessed hormones and cytokines.
No takes yet. Share an insight, caveat, or question.
Famularo et al. (1999) conducted an observational in Cholecystectomy (n=46). Fentanyl anesthesia vs. Isoflurane anesthesia was evaluated on Plasma level of norepinephrine, cortisol, TNFalpha, and IL-6. Fentanyl and isoflurane anesthesia models did not differentially influence plasma changes of hormones and cytokines after open or laparoscopic cholecystectomy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: