Nucleophilic Aromatic Substitution of Hydrogen as a Tool for the Synthesis of Indole and Quinoline Derivatives

Indole and quinoline belong to the most important heterocyclic systems.Although there are numerous methods of syntheses of these heterocycles, new processes leading to these systems have still attracted considerable attention.Nucleophilic Aromatic Substitution of Hydrogen in nitroarenes and other electrophilic arenes opens new rich possibilities for synthesis of indole and quinoline derivatives.In this review a variety of methods for synthesis of these heterocycles based on the initial nucleophilic substitution of hydrogen are discussed. Contents1. Indoles fromo-nitrobenzyl ketones 2.2.2.Indoles from esters of α-(2-nitroaryl)alkanoic acids 2.2.3.Indole derivatives from α-(2-nitroaryl)alkanenitriles 2.3.Formation of indoles via direct interaction of the nitro group with o-carbon substituents 2.4.Indole derivatives from 2-aminobenzyl sulfones 3. QUINOLINES 4.