Key result
Alcohol septal ablation reduces LVOT gradient across all ages but improves hemodynamics slower in younger patients.
Why the study?
The early hemodynamic, morphologic, and clinical changes after alcohol septal ablation in younger versus elderly patients with hypertrophic obstructive cardiomyopathy were not well characterized.
Does age influence the hemodynamic and morphologic outcomes of alcohol septal ablation in patients with hypertrophic obstructive cardiomyopathy?
Comparison
Younger versus elderly patients undergoing alcohol septal ablation
Design
Cohort study
Follow-up
Up to 12 months
Authors
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May inform age-specific counseling on response timelines; leaves open prospective validation of durability differences.
Cohort (n=44)
Single-blind
No
Does age influence the hemodynamic and morphologic outcomes of alcohol septal ablation in patients with hypertrophic obstructive cardiomyopathy?
p-value: p=0.003
Alcohol septal ablation effectively reduces left ventricular outflow gradients in HOCM across all age groups, though younger patients exhibit thicker baseline septums and slower early hemodynamic improvement.
Veselka et al. (2006) conducted a cohort in Hypertrophic Obstructive Cardiomyopathy (HOCM) (n=44). Alcohol septal ablation vs. Age groups (younger vs older) was evaluated on Influence of age on the course of left ventricular outflow tract (LVOT) gradient reduction (p=0.003). Alcohol septal ablation effectively reduced LV outflow tract gradient across all ages, though younger patients experienced a significantly slower hemodynamic improvement (p=0.003).