Key result
EDN1 TaqI polymorphism shows no association with blood pressure levels or variability.
Why the study?
Endothelin is a potent vasoconstrictor that may play a role in physiological regulation of blood pressure, but the effect of the TaqI polymorphism at the EDN1 locus on blood pressure level or variability was unclear.
Does the TaqI polymorphism at the EDN1 locus affect blood pressure levels or variability in healthy individuals?
Observational (n=1,039)
Does the TaqI polymorphism at the EDN1 locus affect blood pressure levels or variability in healthy individuals?
The TaqI polymorphism at the EDN1 locus does not appear to influence blood pressure levels or variability in healthy populations.
No association observed with blood pressure in healthy adults; leaves open EDN1 variant effects in hypertension or other populations.
Endothelin is a peptide reported to be one of the most potent vasoconstrictors known. Presumably, endothelin could play a role in the physiological regulation of blood pressure in healthy or hypertensive people. We have studied a normal restriction fragment length polymorphism (RFLP) at the endothelin-I (EDN1) locus detected with the restriction enzyme TaqI. In three different series comprising 166, 120 and 207 unrelated individuals, we found no evidence for association between genotype in this polymorphism and level of systolic or diastolic blood pressure. In two series of 156 and 117 monozygotic (MZ) twin pairs, respectively, there was no difference between genotypes in within-pair variation in systolic or diastolic blood pressure. Thus neither "level gene" nor "variability gene" effects of normal genes at the EDN1 locus could be detected with the polymorphism analyzed, in healthy population samples.
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Berge et al. (1992) conducted an observational in Healthy (n=1,039). TaqI polymorphism at the endothelin-I (EDN1) locus vs. Alternative genotypes was evaluated on Systolic or diastolic blood pressure level and within-pair variation. The TaqI polymorphism at the endothelin-I (EDN1) locus showed no association with systolic or diastolic blood pressure levels or variability in 1,039 healthy individuals.
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