Key result
Canine hypothyroidism, diabetes, and pancreatitis are linked to elevated serum lipids and altered lipoprotein patterns.
Why the study?
Serum lipid and lipoprotein concentrations and electrophoretic patterns in normal dogs and dogs with secondary hyperlipoproteinemia due to hypothyroidism, diabetes mellitus, and acute pancreatitis were not fully characterized.
How do secondary diseases (hypothyroidism, diabetes mellitus, acute pancreatitis) and their treatments affect serum lipids and lipoproteins in dogs?
Observational
How do secondary diseases (hypothyroidism, diabetes mellitus, acute pancreatitis) and their treatments affect serum lipids and lipoproteins in dogs?
Secondary hyperlipoproteinemia in dogs caused by hypothyroidism or diabetes mellitus can be reversed to near-normal lipid and lipoprotein profiles with appropriate hormone replacement therapy.
May warrant lipid monitoring in dogs with these conditions; leaves open whether therapy reverses profiles in clinical practice.
Concentrations of serum cholesterol, triglyceride, and free glycerol were neasured, and serum lipoprotein electrophoresis was performed in normal dogs and in dogs with hypothyroidism, diabetes mellitus, and acute pancreatitis. Twelve privately owned dogs and 20 Basset Hounds from a research colony served as normal subjects. Privately owned had higher serum lipid concentrations than did research dogs. On electrophorisis of normal dog serum, lipoprotein bands were detected at the beta, pre-beta, alpha-2, and alpha-1 positions. Hypercholesterolemia was associated with increased intensity of the alpha-2-lipoprotein band, and hypertriglyceridemia occurred with increased lipoprotein at the origin, or the beta or pre-beta positions. Hypothyroid dogs had normal lipid values and lipoprotein electrophoretic patterns, hypercholesterolemia with increased intensity of the alpha-2-lipoprotein band, or hypercholesterolemia and hypertiglyceridemia with prominent beta-, pre-beta, and alpha-2-lipoprotein electrophoretic patterns were changed to near-normal values after levothyroxine administration. Diabetic dogs had increased serum cholesterol and triglyceride content and a predominance of lower density lipoproteins, as detected by electrophoresis. Insulin therapy caused the lipid concentrations to decrease and the electrophoretic pattern to revert to near normal. Dogs with acute pancreatitis had moderately increased serum lipid content and electrophoretic patterns characterized by increased intensity of the beta-lipoprotein band and by altered migration of alpha-1-lipoproteins.
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Rogers et al. (1975) conducted an observational in Secondary Hyperlipoproteinemia. Hypothyroidism, diabetes mellitus, and acute pancreatitis vs. Normal dogs was evaluated on Serum cholesterol, triglyceride, free glycerol concentrations, and lipoprotein electrophoretic patterns. Secondary hyperlipoproteinemia in dogs with hypothyroidism, diabetes mellitus, or acute pancreatitis was associated with increased serum lipids and altered lipoprotein electrophoretic patterns.
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