Key result
Early repolarization is ~4 times more common in CAD patients with ventricular arrhythmias.
Why the study?
It is unknown whether early repolarization is associated with ventricular arrhythmias in patients with chronic coronary artery disease.
Is early repolarization associated with an increased risk of ventricular arrhythmias in patients with chronic coronary artery disease?
Comparison
Presence vs absence of early repolarization on standard 12-lead ECG
Design
Case-control study with age- and sex-matched cases and controls
Authors
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Early repolarization, particularly notching in the inferior leads, is associated with an increased risk of life-threatening ventricular arrhythmias in patients with chronic CAD.
Case-Control (n=120)
Is early repolarization associated with an increased risk of ventricular arrhythmias in patients with chronic coronary artery disease?
Absolute Event Rate: 32% vs 8%
p-value: p=0.005
Early repolarization, particularly notching in the inferior leads, is associated with an increased risk of life-threatening ventricular arrhythmias in patients with chronic CAD.
Patel et al. (2010) conducted a case-control in Chronic Coronary Artery Disease (n=120). Early repolarization vs. Matched control subjects without ventricular arrhythmias was evaluated on Presence of early repolarization in 2 or more leads (p=0.005). Early repolarization in 2 or more leads was significantly more common in CAD patients with ventricular arrhythmias compared to matched controls (32% vs 8%, P=0.005).
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