Key result
Biopsy-guided immunosuppression for myocarditis shows no benefit over non-invasive diagnosis for death or transplantation.
Why the study?
The effectiveness of myocarditis therapy depending on the diagnostic approach with or without myocardial biopsy was unclear.
Does the diagnostic approach (myocardial biopsy vs non-invasive algorithm) affect the clinical effectiveness of immunosuppressive therapy in patients with severe and moderate myocarditis?
Cohort (n=83)
Does the diagnostic approach (myocardial biopsy vs non-invasive algorithm) affect the clinical effectiveness of immunosuppressive therapy in patients with severe and moderate myocarditis?
Absolute Event Rate: 13.9% vs 14.9%
Immunosuppressive therapy is similarly effective in patients with severe and moderate myocarditis whether the diagnosis is established via myocardial biopsy or a complex non-invasive strategy.
No takes yet. Share an insight, caveat, or question.
Comparable IST outcomes with non-invasive versus biopsy diagnosis in myocarditis; leaves open need for randomized validation.
Благова et al. (2021) conducted a cohort in Severe and moderate myocarditis (n=83). Myocardial biopsy-guided diagnosis vs. Non-invasive diagnostic algorithm was evaluated on Death or transplantation. Immunosuppressive therapy for myocarditis guided by myocardial biopsy resulted in similar rates of death or transplantation compared to a non-invasive diagnostic strategy (13.9% vs 14.9%).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: