Key result
Metabolic risk factors linked to a ~59% increase in cardiovascular deaths from 1990 to 2019.
Why the study?
Metabolic disorders are the most important risk factors for cardiovascular diseases, but comprehensive analysis and future burden prediction were needed.
Observational
Yes
The absolute global burden of cardiovascular diseases attributable to metabolic risk factors has increased substantially from 1990 to 2019, highlighting the need for enhanced interventions against metabolic disorders.
Urges prioritizing metabolic risk reduction to mitigate rising CV burden; leaves open optimal intervention strategies across populations.
Background: Metabolic disorders are the most important risk factors for cardiovascular diseases (CVDs). The purpose of this study was to systematically analyze and summarize the most recent data by age, sex, region, and time, and to forecast the future burden of diseases. Methods: Data on the burden of CVDs associated with metabolic risk factors were obtained from the Global Burden of Disease (GBD) Study 2019; and then the burden of disease was assessed using the numbers and age-standardized rates (ASR) of deaths, years of life lost (YLLs), years of life lived with disability (YLDs), and disability-adjusted life-years (DALYs) and analyzed for temporal changes, differences in age, region, sex, and socioeconomic aspects; finally, the burden of disease was predicted using an autoregressive integrated moving average (ARIMA) model. Results: From 1990 to 2019, the numbers of deaths, DALYs, YLDs, and YLLs attributed to metabolic risk factors increased by 59.3%, 51.0%, 104.6%, and 47.8%, respectively. The ASR decreased significantly. The burden of metabolic risk factor-associated CVDs was closely related to socioeconomic position and there were major geographical variations; additionally, men had a significantly greater disease burden than women, and the peak shifted later based on the age group. We predicted that the numbers of deaths and DALYs would reach 16.5 million and 324.8 million, respectively, by 2029. Conclusions: The global burden of CVDs associated with metabolic risk factors is considerable and still rising, and more effort is needed to intervene in metabolic disorders.
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Wang et al. (2023) conducted an observational in Cardiovascular diseases associated with metabolic risk factors. Metabolic risk factors was evaluated on Numbers and age-standardized rates of deaths, YLLs, YLDs, and DALYs. Metabolic risk factors accounted for a 59.3% increase in cardiovascular deaths and a 51.0% increase in DALYs from 1990 to 2019, with deaths projected to reach 16.5 million by 2029.
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