Key result
Immulite cTnI assay demonstrates strong analytical performance with ~4% imprecision and broad linearity.
Why the study?
An increasing number of commercial methods for measuring cardiac troponin I are available, necessitating evaluation of the Immulite cTnI assay's analytical and clinical performance.
Population
In vitro samples including purified human cTnI in horse serum and assay diluent (n=20)
Design
Analytical performance study of the Immulite cTnI sandwich immunoassay
Authors
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Supports analytical validation of Immulite cTnI assay; leaves open clinical utility pending outcome studies.
The Immulite cTnI assay demonstrates acceptable analytical performance with low imprecision and good linearity for measuring cardiac troponin I.
Lavoinne et al. (2000) studied this question. Immulite cTnI assay was evaluated on Analytical performance (imprecision, minimal quantified value, linearity). The Immulite cTnI assay demonstrated within- and between-run imprecisions of <3.9% and 3.6% at 1.5 μg/L, with a minimal quantified value of 0.2 μg/L and linearity up to 150 μg/L.