Key result
Systemic parvovirus B19 infection can cause rapid, fatal myocarditis associated with haemophagocytic lympho-histiocytosis.
Why the study?
Parvovirus B19 has recently emerged as a cause of myocarditis, but cases of fulminant PVB19-associated pancarditis with haemophagocytic lympho-histiocytosis in immunocompetent adults are rarely described.
Case Report (n=1)
Highlights the potential for parvovirus B19 to cause unusually severe and rapid fulminant pancarditis and haemophagocytic lympho-histiocytosis leading to death in immunocompetent adults.
Raises awareness of rare fatal parvovirus myocarditis-HLH; hypothesis-generating and leaves open optimal diagnostic strategies.
Myocarditis is a common cardiac disease that is identified on routine postmortem examinations. Initially, coxsackie viruses, other enteroviruses and adenoviruses were thought to be more common causes of myocarditis; however, recently, parvovirus B19 (PVB19) as well as human herpesvirus 6 (HHV6) have entered the arena. We describe autopsy findings of a patient who had a lethal myocarditis with haemophagocytic lympho-histiocytosis in a course of systemic PVB19 infection. The present case illustrates the unusually severe and rapid course of PVB19 myocarditis with associated haemophagocytic lympho-histiocytosis leading to death.
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Bal et al. (2009) conducted a case report in Fulminant parvovirus B19-associated pancarditis with haemophagocytic lympho-histiocytosis (n=1). Systemic parvovirus B19 infection was evaluated on Death and autopsy findings. Systemic parvovirus B19 infection can cause an unusually severe and rapid course of myocarditis with associated haemophagocytic lympho-histiocytosis leading to death.
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