Key result
Coronary artery ectasia is linked to ~113% higher plasma eosinophil counts versus normal angiograms.
Why the study?
The pathophysiology of coronary artery ectasia (CAE) has not been clearly identified, and the role of eosinophils in CAE is unclear.
Are plasma eosinophil count, MPV, and NLR elevated in patients with coronary artery ectasia compared to controls?
Case-Control (n=80)
No
Are plasma eosinophil count, MPV, and NLR elevated in patients with coronary artery ectasia compared to controls?
Absolute Event Rate: 0.198% vs 0.093%
p-value: p=0.002
Patients with coronary artery ectasia have significantly higher eosinophil counts, MPV, and NLR compared to controls, suggesting a potential role of inflammation and thrombosis in its pathophysiology.
May reflect inflammatory processes in CAE; hypothesis-generating and should not yet change practice.
BACKGROUND: The pathophysiology of coronary artery ectasia (CAE) has not been clearly identified, although multiple abnormalities including arteritis, endothelial dysfunction, and atherothrombosis have been reported. It is known that eosinophils play an important role in inflammation and thrombosis. Also vascular anomalies such as aneurysm have been noted in patients with hypereosinophilic syndromes. We aimed to compare the numbers of eosinophil counts of the patients CAE versus controls. METHODS: This study included 50 CAE patients (20 male, mean age 60.26 ± 10.6 years) and 30 control person (10 male, mean age 57.86 ± 11.6 years). These participants were performed concurrent routine biochemical tests and neutrophil, lymphocyte, eosinophil count and mean platelet volume (MPV) on whole blood count. These parameters were compared between groups. RESULTS: Baseline characteristics of the study groups were comparable. CAE patients had a higher MPV value, eosinophil, neutrophil lymphocyte ratio (NLR) than controls (8.5 ± 1 vs 76.2 ± 1.6 fl and 0.198 ± 0.14 vs 0.093 ± 0.058 and 3.0 ± 2.5vs 1.14 ± 0.9; P < 0.001, 0.002 and 0.028 respectively). CONCLUSION: As a result, our study revealed a relationship between eosinophil count, NLR and MPV in patients with CAE.
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Mehmet Demir (2013) conducted a case-control in Coronary Artery Ectasia (n=80). Plasma eosinophil count vs. Controls with normal coronary angiograms was evaluated on Plasma eosinophil count (10^3/μL) (p=0.002). Patients with coronary artery ectasia had significantly higher plasma eosinophil counts compared to controls with normal coronary angiograms (0.198 vs 0.093 10^3/μL, p=0.002).
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